Be at the Forefront of Innovation
Microbiome Innovation for Women’s Intimate Health
Join the P.Happi® Healthcare Professional Programme to access clinical insights, evaluation opportunities and professional resources on microbiome-focused intimate health.
P.Happi® at a glance
• UK-made non-antibiotic
• Hormone-free topical serum
• Live, protective bacteria for intimate self-care (vulva, perineum)
• Powered by smart natural bacterium B.Y.M.® 1405 (Bdellovibrio)
• Protecting from disruptive bacteria like E.coli.
Connect With The Team
Relevant Specialists Include:
Urologists & Urogynaecologists
Gynaecologists
GPs with Women’s Health Focus
Pelvic Health Physiotherapists
Menopause Specialists
Fertility and IVF Specialists
Sexual Health Clinicians
Integrative Women’s Health Practitioners
Together, we can offer women of all life stages a safe, effective, and microbiome-friendly solution that supports comfort and confidence in daily life.
The Unmet Need in Recurrent UTI & Intimate Microbiome Imbalance
Recurrent UTIs represent a substantial and ongoing clinical burden across primary and secondary care and the impact extends well beyond individual discomfort:
1.6 million women in Britain affected
Up to 70% reinfection within 12 months¹
3–10 million GP consultations annually²
£604+ million NHS cost burden³
Ongoing Clinical Burden
Chronic and recurrent urinary tract infections remain one of the most common and persistent challenges in women’s health.
The Recurrence Cycle
Despite appropriate treatment, recurrence remains high. Many women cycle between infection, antibiotic treatment and temporary relief without addressing underlying microbiome vulnerability.
Complementary Support
There is a growing need for non-antibiotic, microbiome-supportive strategies that complement standard care and align with stewardship principles.
Get To Know P.Happi®
P.Happi® is a topical intimate serum designed to support the vulvo-vaginal microbiome. It contains the live beneficial bacterium Bdellovibrio bacteriovorus, which selectively targets certain Gram-negative bacteria associated with imbalance.
Key characteristics:
Cosmetic classification and available as self-care product in UK&I and EU (non-prescription)
Hormone-free
Non-antibiotic
Topical, non-systemic
Contains live Bdellovibrio bacteriovorus
Designed for daily external application
Applied externally to the vulval area, P.Happi® supports microbiome balance without disrupting broader microbial communities.
Bdellovibrio bacteriovorus (B.Y.M.® 1405) is the organism that powers P.Happi® and has been the subject of research and peer reviewed papers for decades. The technology has been patented by the company.
Key characteristics:
Selectively targets Gram-negative bacteria only (e.g. E.coli)
Naturally occuring predatory bacterium
Does not attack Lactobacilli
Does not colonise permanently
Does not behave like broad-spectrum antibiotics
Unlike probiotics that introduce competing strains, Bdellovibrio acts by targeting specific Gram-negative bacteria associated with imbalance.
Clinically, this can be visualised as a selective “predator” mechanism. Sometimes described as behaving like a microscopic Pac-Man, attaching to and breaking down certain Gram-negative bacteria rather than broadly suppressing microbial communities. This selective predatory behaviour makes it a novel and differentiated microbiome-support approach.
Visualisation of microscopic Pac-Man
Science you can see within 24 hours
The Science: B.Y.M.® 1405 selectively targets Gram-negative bacteria, e.g., E. coli
In the absence of B.Y.M.® 1405, Gram-negative bacteria remain at high levels over 24-30 h.
When B.Y.M.® 1405 is added, the density of Gram-negative bacteria drops and neither E. coli nor Pseudomonas colonies can be detected on culture plates after 24 h (limit of detection = 100 cfu/ml).
Further Reading:
Understanding the intimate microbiome: The Intimate Microbiome – Separate Systems, One Connected Network
P.Happi® builds on decades of microbiology research on Bdellovibrio bacteriovorus. Early clinical evaluation and user data suggest meaningful improvements in symptoms associated with intimate microbiome imbalance.
In a UK 24-week feasibility study* with peri- and postmenopausal women, P.Happi®:
Halved UTI recurrence compared with baseline
Significantly improved 9 urogenital symptoms, including dryness, urgency and bladder pain
Improved quality of life and sexual wellbeing
Achieved high adherence (91.8%) and high satisfaction (4.3/5)
P.Happi® demonstrated a strong safety profile and is suitable where hormonal treatments are unsuitable or undesirable.
Further clinical evaluation and ongoing practitioner feedback continue to inform product development. Fill out the form below to connect with us and stay in touch!
→ Connect with us
*Publication pending.
6-Month Study Shows Statistically Significant Improvement in Bladder & Intimate Symptoms
Many commonly used options focus on a single mechanism – flushing bacteria, adding probiotic strains, or providing moisture. P.Happi® uses a different approach: a live beneficial bacterium (Bdellovibrio bacteriovorus) that selectively targets certain Gram-negative bacteria associated with imbalance while supporting the broader intimate microbiome. The comparison below highlights how this approach differs from other commonly used options.
How It Works
Application Method
Made With Live Bacteria
Target Area
Targets broad
range of bacteria
Microbiome support
Dryness support
£/Price per day
Stops bacteria getting
into the intimate area
Targets the root cause
Direct Topical
Protects the whole intimate area
Yes
Range of Gram-negative
89p
D-MANNOSE & CRANBERRY
Stops bacteria sticking
to bladder wall
Flushes them out
Indirect Oral
Bladder Only
No
Mainly E.coli
66p - £2.29
PROBIOTICS
Adds good bacteria
to the vagina
Indirect Oral
Vagina Only
No
Do not selectively impact pathogens
79p- £1.30
MOISTURISERS & LUBES
Moisturises dry skin
Direct Topical
Vagina Only
No
75p
Swipe Right
P.Happi® is developed in our dedicated London laboratory by an in-house team of female scientists, including researchers focused on advancing women’s intimate health. For over five years, the team has been developing and refining our B.Y.M. Technology.
Every day they work on testing, optimising performance and exploring new microbiome-focused ideas to ensure the product remains safe, stable and effective – helping us raise the standard of care in intimate health.
Safely Created by Women, for Women
Tested and verified by third party labs, safety assesments can be provided on request
Connect with our Practitioner Team
Which Patients May Benefit?
Recurrent or
Persistent Symptoms
Recurrent UTIs
Ongoing vulvo-vaginal irritation or imbalance
Symptoms despite negative cultures
Hormonal or Microbiome Vulnerability
Peri-/post-menopause
Postpartum or breastfeeding
Frequent antibiotic exposure
Unable or preferring to avoid local oestrogen therapy
Chronic or Sensitive Vulval Conditions
Vulval skin fragility (e.g. lichen sclerosus, alongside prescribed care)
Seeking microbiome-conscious support
Recommended by Clinical and Scientific Experts
"Traditional treatments often rely on antibiotics, which can disrupt natural flora and lead to recurrence. P.Happi offers a promising, non-disruptive alternative—supporting the body’s own protective bacteria without broad-spectrum antimicrobials. It meets a genuine clinical need for sustainable, microbiome-friendly care in women’s intimate health."
Dr Phillip Hay
Consultant in Sexual Health at Guys & St Tomas'
NHS Foundation Trust
"I'm excited by this innovative product. It addresses a critical need for women-centred solutions that support a healthy microbiome across the life course, from adolescence to post-menopause. This could reduce reliance on traditional treatments for conditions like recurrent UTIs, empowering women at every stage"
Dr Rhiannon Bray
Consultant Urogynaecologist, New Victoria Hospital
"This innovative product fills a gap...By promoting a healthy microbiome it may reduce our reliance on traditional approaches..."
Mr Sachin Malde
Urological Surgeon at Guy's and St Thomas' Hospital
"I am passionate about encouraging patients to recognise the importance of a healthy microbiome...Use of a cream, which helps to reduce the bad bacteria without harming the good ones, is surely a step in the right direction..."
Dr Catriona Anderson
MBCHB, BSC (HONS), MRCGP, DFSRH
"There is a pressing need for innovation in this space to develop more women-centred solutions to ultimately optimise women's wellbeing and quality of life"
Professor Nick Panay
MD, BSC, MRCOG, MFSRH, Consultant, Gynaecologist
"I really love the product & think it makes so much sense for perimenopausal/menopausal ladies due to the fact that their vulval/vaginal microbiome will always be out of balance due to the disruption of the acid mantle from lack of Oestrogen. I'm very excited to introduce this into practice."
Ruth Bescoby, Advanced Nurse Practitioner
Recommended by Clinical and Scientific Experts
"Traditional treatments often rely on antibiotics, which can disrupt natural flora and lead to recurrence. P.Happi offers a promising, non-disruptive alternative—supporting the body’s own protective bacteria without broad-spectrum antimicrobials. It meets a genuine clinical need for sustainable, microbiome-friendly care in women’s intimate health."
Dr Phillip Hay
Consultant in Sexual Health at Guys & St Thomas' NHS Foundation Trust
"I'm excited by this innovative product. It addresses a critical need for women-centred solutions that support a healthy microbiome across the life course, from adolescence to post-menopause. This could reduce reliance on traditional treatments for conditions like recurrent UTIs, empowering women at every stage"
Dr Rhiannon Bray
Consultant Urogynaecologist, New Victoria Hospital
"This innovative product fills a gap...By promoting a healthy microbiome it may reduce our reliance on traditional approaches..."
Mr Sachin Malde
Urological Surgeon at Guy's and St Thomas' Hospital
"I am passionate about encouraging patients to recognise the importance of a healthy microbiome...Use of a cream, which helps to reduce the bad bacteria without harming the good ones, is surely a step in the right direction..."
Dr Catriona Anderson
MBCHB, BSC (HONS), MRCGP, DFSRH
"There is a pressing need for innovation in this space to develop more women-centred solutions to ultimately optimise women's wellbeing and quality of life"
Professor Nick Panay
MD, BSC, MRCOG, MFSRH, Consultant, Gynaecologist
"I really love the product & think it makes so much sense for perimenopausal/menopausal ladies due to the fact that their vulval/vaginal microbiome will always be out of balance due to the disruption of the acid mantle from lack of Oestrogen. I'm very excited to introduce this into practice."
Ruth Bescoby, Advanced Nurse Practitioner
Join the P.Happi® Clinical Network
As a P.Happi® Healthcare Partner, You Receive:
Product Evaluation
Access to evaluate P.Happi® and request practitioner samples. Optional consideration for inclusion in our curated HCP guide.
Insights
Early access to research updates, webinars, case discussions and emerging microbiome developments.
Resources
Educational materials and patient leaflets designed to support confident clinical conversations.
We aim to build a collaborative, clinician-informed community focused on advancing women’s intimate health. If this sounds like you, we’d love to have you on board!
Get In Touch
Frequently Asked Questions
Have another question?
Contact Us
Is P.Happi® a treatment for UTIs?
No. P.Happi® is not a treatment and does not replace antibiotics when clinically indicated.
Can it be used alongside antibiotics?
Yes. As a topical cosmetic serum, it may be used alongside antibiotic treatment as part of a broader supportive approach.
Can it be used proactively?
P.Happi® is intended to support the natural balance of the intimate microbiome during periods of vulnerability (e.g. post-antibiotics, hormonal change, stress or sexual activity). It is not positioned as a preventative treatment for infection.
What is the regulatory classification?
P.Happi® is classified as a cosmetic intimate care product. It is not a medicinal product and does not claim to treat, cure or prevent disease.
Does it disrupt beneficial flora?
Bdellovibrio selectively targets Gram-negative bacteria and does not act as a broad-spectrum antibiotic.
How is this different from probiotics?
Probiotics introduce bacterial strains. Bdellovibrio works by selectively breaking down certain Gram-negative bacteria associated with imbalance.
How long does it survive?
Bdellovibrio’s survival depends on environmental conditions and the presence of susceptible bacteria. It does not colonise permanently and does not establish long-term residence in the microbiome.
How should patients use it?
P.Happi® is designed for daily external application to the vulval area as part of a regular intimate care routine. We recommend applying twice a day. It is non-systemic and not intended for internal use.
When can patients expect to feel a difference?
From first use: moisturising and soothing comfort. After ~2 weeks: many women report a growing sense of balance and support. After ~3 months: ongoing microbiome support as part of a regular routine.
Is it suitable for long-term use?
Yes. P.Happi® is designed for ongoing daily use as part of regular intimate care.
Does P.Happi® contain hormones?
No. P.Happi® is hormone-free and does not contain oestrogen, progesterone or phytoestrogens.
Can it be used in menopause?
Yes. P.Happi® is suitable for peri- and post-menopausal women.
Can it be used alongside vaginal oestrogen?
Yes. As a topical, hormone-free serum, P.Happi® may be used alongside local oestrogen therapy. It does not interfere with hormonal treatments.
Is it suitable during pregnancy or breastfeeding?
As with any intimate care product, use during pregnancy or breastfeeding should be guided by clinical judgement. P.Happi® is topical and non-systemic.
How can I recommend P.Happi® to my patients?
Healthcare professionals may recommend P.Happi® within their clinical discretion as part of a broader discussion around intimate microbiome support.
Many practitioners choose to share a unique practitioner code that allows patients to purchase P.Happi® directly from our website. This enables patients to order independently while maintaining professional separation from product distribution.
Patient information leaflets and educational materials are also available for use in clinic.
Do I need to stock P.Happi® in my clinic?
No. Most practitioners prefer to recommend P.Happi® via a practitioner code so patients can order directly online. If you are interested in in-clinic stock options for patient convenience, our team can provide further information.
Can I try P.Happi® before recommending it to patients?
Yes. Many healthcare professionals prefer to experience a product themselves before discussing it with patients.
Members of the P.Happi® Clinical Network may request a complimentary practitioner sample to review the product. Simply complete the sign-up form and our team will be in touch with details.
Do you provide materials to support patient conversations?
Yes. Healthcare partners receive access to patient information leaflets, educational resources and clinical background materials designed to support informed discussions about microbiome-conscious intimate care.
1. C.U.T.I.C. What is chronic UTI? Chronic Urinary Tract Infection Campaign. Available at: https://cutic.co.uk/what-is-chronic-uti/ 2. Health Innovation East Midlands. Digital UTI Pathway Evaluation. 2022. Available at: https://healthinnovation-em.org.uk/images/Digital_UTI_Pathway_Evaluation_-_Final_v270720.pdf 3. Public Health England. Understanding the burden of urinary tract infection hospitalisations in England. UK Health Security Agency, 2024. Available at: https://www.gov.uk/government/publications/understanding-the-burden-of-uti-hospitalisations-in-england 4. Publication pending.